Darcie and Karolina’s image of the vimentin-mScarlet mouse cerebellum has been chosen as a winner of the Cool Science Image Contest at UW-Madison!
https://news.wisc.edu/the-2022-winners-cool-science-image-contest/
The winners will be exhibited through December at the McPherson Eye Research Institute's gallery on the ninth floor in the Wisconsin Institutes for Medical Research, 111 Highland Ave. There will be a small reception to open the exhibit on Thursday, Sept. 29, from 4:30 to 6:30 p.m.
Congrats to Bo for being named Runner-up for the 2022 Bennett Hiner Research Award from the Wisconsin Neurological Society! This award is in memory of Bennett Hiner, son of long-time Society member Dr. Bradley Hiner. Bennett passed away unexpectedly in November of 2011. He was a leader in his medical school class at the University of Southern California and actively involved in neuroscience research.
Congratulations!
As part of this award, Bo gets complimentary registration to SFN as well as a stipend to offset travel costs. Additionally, she will present her work and attend trainings. Congrats Bo on this competitive award!
Adult fibroblasts use aggresomes only in distinct cell-states
Christopher S. Morrow, Zachary P. Arndt, Payton C. Klosa, Bo Peng, Eden Y. Zewdie, Bérénice A. Benayoun, Darcie L. Moore
Abstract
The aggresome is a protein turnover system in which proteins are trafficked along microtubules to the centrosome for degradation. Despite extensive focus on aggresomes in immortalized cell lines, it remains unclear if the aggresome is conserved in all primary cells and all cell-states. Here we examined the aggresome in primary adult mouse dermal fibroblasts shifted into four distinct cell-states. We found that in response to proteasome inhibition, quiescent and immortalized fibroblasts formed aggresomes, whereas proliferating and senescent fibroblasts did not. Using this model, we generated a resource to provide a characterization of the proteostasis networks in which the aggresome is used and transcriptomic features associated with the presence or absence of aggresome formation. Using this resource, we validate a previously reported role for p38 MAPK signaling in aggresome formation and identify TAK1 as a novel driver of aggresome formation upstream of p38 MAPKs. Together, our data demonstrate that the aggresome is a non-universal protein degradation system which can be used cell-state specifically and provide a resource for studying aggresome formation and function.
Thanks to Sophy Vuong for her hard work this summer as part of the Biological Interactions program for undergraduates. Sophy came to us from New Jersey, and worked on our project on vimentin translational repression. Good luck this fall Sophy, and hope to see you again soon!
The Jerzy Rose Neuroscience Award has been presented annually since 1982 to the UW-Madison graduate student whose thesis research in the neurosciences is deemed most original and significant by members of the committee.
The selection committee was very impressed by the scope and depth of Chris' PhD thesis work and its originality, as well as the non-scientific version of Chris' thesis and Chris' passion and efforts to serve the community.
Definitely something to celebrate.
The Bouchet Society provides scholars with a network of peers who exemplify character, leadership, scholarship, service, and advocacy for those who have been traditionally underrepresented in the academy. Induction into the Bouchet Society is both an individual honor and a welcome into this wider network of like-minded scholars.
Congratulations Bo!
Bo has been selected to give a talk as part of the RNA Collaborative Seminar Series (https://www.rnasociety.org/rna-collaborative-seminar-series) of the RNA Society, and also received a trainee membership to the RNA Society for 1 year. Congrats Bo!
Congrats to Chris and Tiaira for acceptance of their manuscript to Star Protocols entitled: Fluorescent tagging of endogenous proteins with CRISPR/Cas9 in primary mouse neural stem cells
The President of the American Aging Association is pleased to announce the following Travel Award recipients for the 49th annual meeting “Metabolism of Aging’.
Walter R. Nicolai Award: Aggresome mediated neural stem cell quiescence exit
DR. Chris Morrow, University of Wisconsin - Madison
The Walter R. Nicolai Award was established in 1982 in the name of Walter Nicolai (a long-time board member of AGE who was killed in a skiing accident in 1982) for meritorious research by a graduate or medical student in the area of biomedical gerontology.
Congrats to our new Dr. Morrow!
Well done Chris!
Zachary Ziemba joins us after recently graduating with his Masters from UMichigan! Welcome Zachary!
We’re happy to have a new research intern join our lab this week, newly graduated from Valparaiso University with a Bachelor’s of Science in Chemistry and Biology. Time to celebrate with ice cream!
Welcome Payton!
The Wisconsin Initiative for Science Literacy invites doctoral candidates in science and engineering
to include a chapter in their Ph.D. thesis that describes their scholarly research to non-science audiences.
Chris won for his chapter on "Finding the bottleneck in brain rejuvenation: mechanisms underlying
neural stem cell quiescence exit."
Congratulations!
http://scifun.org/Thesis_Awards/thesis_awards.html
Congrats to Chris for being the best short talk winner at the Madison Scholars Symposium! https://biologyofaging.wisc.edu/2021-virtual-madison-scholars-symposium/
Bo’s F30 proposal was funded on its first try from NIH! Congratulations Bo!
Darcie will Chair a Stem cell aging symposium for the Aging Science Talks community. Speakers include:
Saul Villeda, UCSF
Marlen Knobloch, University of Lausanne, Switzerland
Yukiko Yamashita, MIT/Whitehead
Maria Llorens-Martin, Universidad Autonoma de Madrid, Spain
One of Chris’ reviews written during our safer-at-home time will be published in Cytoskeleton and is online now! Congrats Chris!
https://pubmed.ncbi.nlm.nih.gov/33190414/
PMID: 33190414
Another farewell goes out to our lab manager Kayla, who has been with the lab for 4 years! We wish you all the best in your next steps! We’ll miss you!
